Title: Distance from Sub-Saharan Africa Predicts Mutational Load in Diverse Human Genomes
نویسندگان
چکیده
1 Stony Brook University, SUNY, Department of Ecology and Evolution, Stony Brook, NY 11794 2 Institute of Ecology and Evolution, University of Berne, Berne, Switzerland 3012. 3 Stanford University School of Medicine, Department of Genetics, Stanford, CA 94305 4 Foundation Jean Dausset, Centre d'Etude du Polymorphisme Humain, Paris, France 75010 5 University of Michigan Medical School, Department of Human Genetics and Department of Computational Medicine and Bioinformatics, Ann Arbor, MI 48109 6 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 7 Interfaculty Bioinformatics Unit, University of Berne, Berne, Switzerland 3012
منابع مشابه
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.
The Out-of-Africa (OOA) dispersal ∼ 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase of mutational load in populations undergoing serial founder effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from seven geographically d...
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